UNEXPECTED TOP-LEVEL EXCEPTION: java.lang.IllegalArgumentException: method ID not in [0, 0xffff]: 65536 
    at com.android.dx.merge.DexMerger$6.updateIndex(DexMerger.java:501) 
    at com.android.dx.merge.DexMerger$IdMerger.mergeSorted(DexMerger.java:276) 
    at com.android.dx.merge.DexMerger.mergeMethodIds(DexMerger.java:490) 
    at com.android.dx.merge.DexMerger.mergeDexes(DexMerger.java:167) 
    at com.android.dx.merge.DexMerger.merge(DexMerger.java:188) 
    at com.android.dx.command.dexer.Main.mergeLibraryDexBuffers(Main.java:439) 
    at com.android.dx.command.dexer.Main.runMonoDex(Main.java:287) 
    at com.android.dx.command.dexer.Main.run(Main.java:230) 
    at com.android.dx.command.dexer.Main.main(Main.java:199) 
    at com.android.dx.command.Main.main(Main.java:103):Derp:dexDerpDebug FAILED

android {
    compileSdkVersion 21
    buildToolsVersion "21.1.0"
    defaultConfig {
        ...
        minSdkVersion 14
        targetSdkVersion 21
        ...
        // Enabling multidex support.
        multiDexEnabled true
    }
    ...
}
dependencies {
compile 'com.android.support:multidex:1.0.0'
}

?xml version="1.0" encoding="utf-8"?>
<manifest xmlns:android="http://schemas.android.com/apk/res/android"
package="com.example.android.multidex.myapplication">
<application
...
android:name="android.support.multidex.MultiDexApplication">
...
</application>
</manifest>

@Override
protected void attachBaseContext(Context base) {
    super.attachBaseContext(base);
    MultiDex.install(this);     
}

adb logcat -v time > log.txt

public class App extends Application {
    @Override
    protected void attachBaseContext(Context base) {
        super .attachBaseContext(base);
        LogUtils.d( "loadDex", "App attachBaseContext ");
        if (!quickStart()) {
            if (needWait(base)){
                waitForDexopt(base);
            }
            MultiDex.install (this );
        } else {
            return;
        }
    }
    @Override
    public void onCreate() {
        super .onCreate();
        if (quickStart()) {
            return;
        }
        ...
    }
    public boolean quickStart() {
        if (StringUtils.contains( getCurProcessName(this), ":mini")) {
            LogUtils.d( "loadDex", ":mini start!");
            return true;
        }
        return false ;
    }
    //neead wait for dexopt ?
    private boolean needWait(Context context){
        String flag = get2thDexSHA1(context);
        LogUtils.d( "loadDex", "dex2-sha1 "+flag);
        SharedPreferences sp = context.getSharedPreferences(
                PackageUtil.getPackageInfo(context). versionName, MODE_MULTI_PROCESS);
        String saveValue = sp.getString(KEY_DEX2_SHA1, "");
        return !StringUtils.equals(flag,saveValue);
    }
    /**
     * Get classes.dex file signature
     * @param context
     * @return
     */
    private String get2thDexSHA1(Context context) {
        ApplicationInfo ai = context.getApplicationInfo();
        String source = ai.sourceDir;
        try {
            JarFile jar = new JarFile(source);
            Manifest mf = jar.getManifest();
            Map<String, Attributes> map = mf.getEntries();
            Attributes a = map.get("classes2.dex");
            return a.getValue("SHA1-Digest");
        } catch (Exception e) {
            e.printStackTrace();
        }
        return null ;
    }
    // optDex finish 
    public void installFinish(Context context){
        SharedPreferences sp = context.getSharedPreferences(
                PackageUtil.getPackageInfo(context).versionName, MODE_MULTI_PROCESS);
        sp.edit().putString(KEY_DEX2_SHA1,get2thDexSHA1(context)).commit();
    }
    public static String getCurProcessName(Context context) {
        try {
            int pid = android.os.Process.myPid();
            ActivityManager mActivityManager = (ActivityManager) context
                    .getSystemService(Context. ACTIVITY_SERVICE);
            for (ActivityManager.RunningAppProcessInfo appProcess : mActivityManager
                    .getRunningAppProcesses()) {
                if (appProcess.pid == pid) {
                    return appProcess. processName;
                }
            }
        } catch (Exception e) {
            // ignore
        }
        return null ;
    }
    public void waitForDexopt(Context base) {
        Intent intent = new Intent();
        ComponentName componentName = new
                ComponentName( "com.zongwu", LoadResActivity.class.getName());
        intent.setComponent(componentName);
        intent.addFlags(Intent.FLAG_ACTIVITY_NEW_TASK);
        base.startActivity(intent);
        long startWait = System.currentTimeMillis ();
        long waitTime = 10 * 1000 ;
        if (Build.VERSION.SDK_INT < Build.VERSION_CODES.HONEYCOMB_MR1 ) {
            waitTime = 20 * 1000 ;//实测发现某些场景下有些2.3版本有可能10s都不能完成optdex
        }
        while (needWait(base)) {
            try {
                long nowWait = System.currentTimeMillis() - startWait;
                LogUtils.d("loadDex" , "wait ms :" + nowWait);
                if (nowWait >= waitTime) {
                    return;
                }
                Thread.sleep(200 );
            } catch (InterruptedException e) {
                e.printStackTrace();
            }
        }
    }
}

public class LoadResActivity extends Activity {
    @Override
    public void onCreate(Bundle savedInstanceState) {
        requestWindowFeature(Window.FEATURE_NO_TITLE);
        super .onCreate(savedInstanceState);
        getWindow().setFlags(WindowManager.LayoutParams.FLAG_FULLSCREEN , WindowManager.LayoutParams.FLAG_FULLSCREEN );
        overridePendingTransition(R.anim.null_anim, R.anim.null_anim);
        setContentView(R.layout.layout_load);      
        new LoadDexTask().execute();
    }
    class LoadDexTask extends AsyncTask {
        @Override
        protected Object doInBackground(Object[] params) {
            try {
                MultiDex.install(getApplication());
                LogUtils.d("loadDex" , "install finish" );
                ((App) getApplication()).installFinish(getApplication());
            } catch (Exception e) {
                LogUtils.e("loadDex" , e.getLocalizedMessage());
            }
            return null;
        }
        @Override
        protected void onPostExecute(Object o) {
            LogUtils.d( "loadDex", "get install finish");
            finish();
            System.exit( 0);
        }
    }
    @Override
    public void onBackPressed() {
        //cannot backpress
    }

<activity
    android:name= "com.zongwu.LoadResActivity"
    android:launchMode= "singleTask"
    android:process= ":mini"
    android:alwaysRetainTaskState= "false"
    android:excludeFromRecents= "true"
    android:screenOrientation= "portrait" />
<activity
    android:name= "com.zongwu.WelcomeActivity"
    android:launchMode= "singleTop"
    android:screenOrientation= "portrait">
    <intent-filter >
        <action android:name="android.intent.action.MAIN"/>
        <category android:name="android.intent.category.LAUNCHER"/>
    </intent-filter >
</activity>

<set xmlns:android="http://schemas.android.com/apk/res/android">
    <alpha
        android:fromAlpha="1.0"
        android:toAlpha="1.0"
        android:duration="550"/>
</set>